Capsaicin

  • n-(4-Hydroxy-3-methoxybenzyl-8-methylnon-trans-6-enamide
  • Styptysat
  • trans-8-Methyl-n-vanillyl-6-nonenamide
Formula
C18H27NO3
Structure
Description
Monoclinic, rectangular plates, scales from petroleum ether.
Uses
Flavoring agent in foods, additive to topical creams, used in pepper mace.

Registry Numbers and Inventories.
CAS
404-86-4
EC (EINECS/ELINCS)
206-969-8
RTECS
RA8530000
RTECS class
Tumorigen; Mutagen; Natural Product
Merck
12,1811
Beilstein/Gmelin
2816484
Beilstein Reference
4-13-00-02588
EPA OPP
70701
Swiss Giftliste 1
G-38215
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C18H27NO3
Formula mass
305.42
Melting point, °C
66.1
Boiling point, °C
210-220 (0.01 torr):
Solubility in water
practically insoluble in cold water
Partition coefficient, pKow
3.04

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
2
Exposure effects
stimulates pain fibers and release immunoreactive somatostatin.
   Ingestion
Biting plants which contain capsaicin may cause acute stinging of the lips, tongue, and oral mucosa, which may lead to vomiting and diarrhea. Epithelial cell sloughing or mild mucosal bleeding may occur.
   Inhalation
Capsaicin vapors, especially from burning, may cause significant pulmonary irritation and prolonged cough. Pulmonary edema and bronchospasm may occur.
   Skin
Irritation, erythema, and burning pain without vesiculation often occurs when applied topically to human skin.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.