Captafol

  • N-(1,1,2,2-Tetrachloroethylthio)cyclohex-4-ene-1,2-dicarboximide
  • 3a,4,7,7a-Tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide
  • Difolitan
Formula
C10H9Cl4NO2S
Structure
Description
White, solid. Slight, characteristic pungent odor.
Uses
Fungicide.

Registry Numbers and Inventories.
CAS
2425-06-1
EC (EINECS/ELINCS)
219-363-3
EC Index Number
613-046-00-7
EC Class
Carcinogenic Category 2; Sensitising; Dangerous for the Environment
RTECS
GW4900000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
2773
Merck
12,1814
Beilstein/Gmelin
1543712
Beilstein Reference
5-21-10-00136
EPA OPP
81702
Swiss Giftliste 1
G-2675
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H9Cl4NO2S
Formula mass
349.06
Melting point, °C
160
Vapor density (air=1)
12
Solubility in water
Insoluble
Partition coefficient, pKow
3.83

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
Slowly hydrolyzed in aqueous emulsion or suspension. Rapidly hydrolyzed in acidic and alkaline media. Decomposes slowly at the melting point.
Incompatibilities
Incompatible with highly alkaline materials. Avoid contact with acids, acid vapors, strong oxidizers.
Decomposition
When heated to decomposition it emits very toxic fumes of hydrogen chloride, oxides of nitrogen and oxides of sulfur.

Fire.
Fire fighting
Use method most appropriate to fight surrounding fire.
Fire potential
Non-Combustible
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure limit(s)
TLV: ppm; 0.1 mg/m3 (skin) (ACGIH 1993-1993). NIOSH REL: Ca TWA 0.1 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen
Carcinogin
I-2A, CP65
Poison_Class
4
Exposure effects
The phthalimide fungicides contain the phthalimide moiety in common with phthalidomide, a known human teratogen. Captan has been teratogenic, fetotoxic, and/or embryotoxic in a variety of rodent species and caused stillbirths in dogs. Folpet was teratogenic in rabbits, chicks, and hamsters. Captafol has been embryo- or fetotoxic in experimental animals. <br>Captan, folpet, and captafol have all induced testicular degeneration in laboratory animals.
   Ingestion
Nausea, vomiting, and diarrhea may follow ingestion.
   Inhalation
Folpet is a respiratory tract irritant and can produce occupational asthma.
   Skin
Irritant and allergic contact dermatitis have been reported with captan, folpet, and captafol.
   Eyes
Folpet is an irritant of the eyes and mucous membranes.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. Remove material from skin immediately. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
2773
Response guide
Hazard class
6.1