Captopril

  • (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
  • Aceplus
  • Acepress
  • Acepril
  • Alopresin
  • Capoten
Formula
C9H15NO3S
Structure
Description
White to off-white, crystalline powder. Slight acid-sulfhydryl odor.
Uses
antihypertensive drug

Registry Numbers and Inventories.
CAS
62571-86-2
EC (EINECS/ELINCS)
263-607-1
RTECS
UY0550000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,1817
Beilstein/Gmelin
477887
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C9H15NO3S
Formula mass
217.29
Melting point, °C
103 - 105
Solubility in water
freely soluble
pKa/pKb
3.7 (pKa)
Partition coefficient, pKow
0.34

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides.
Decomposition
Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use foam, dry chemical, or carbon dioxide.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May be harmful if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin. May cause sensitization by skin contact.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.