Carbamazepine

  • Dibenz(b,f)azepine-5-carboxamide
  • 5-Carbamoyl-5H-dibenz(b,f)azepine
  • 5-Carbamoyldibenzo(b,f)azepine
  • Carbazepine
  • 5H-Dibenz(b,f)azepine-5-carboxamide
  • Telesmin
Formula
C15H12N2O
Structure
Description
Crystals from absorption in ethanol + benzene.
Uses
Medication.

Registry Numbers and Inventories.
CAS
298-46-4
EC (EINECS/ELINCS)
206-062-7
RTECS
HN8225000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,1826
Beilstein/Gmelin
1246090
Beilstein Reference
5-20-08-00247
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C15H12N2O
Formula mass
236.27
Melting point, °C
190 - 192
Boiling point, °C
411
Vapor pressure, mmHg
6E-7 (25 C)
Density
1.296 g/cm3 (-115 C)
Solubility in water
Insoluble
pKa/pKb
13.94 (pKa)
Partition coefficient, pKow
2.67
Heat of fusion
25.0 kJ/mol
Heat of vaporization
66.3 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
202
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
Ataxia, slurred speech, nystagmus, dystonias, and varying degrees of CNS depression are common. Myoclonic activity, seizures and abnormal tendon reflexes have been reported. Cyclic coma, possibly due to delayed absorption, has been reported.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.