Chloral hydrate

  • 2,2,2-Trichloro-1,1-ethanediol
  • Trichloroacetaldehyde monohydrate
  • 2,2,2-Trichloroethane-1,1-diol
Formula
Cl3CCH(OH)2
Structure
Description
Transparent colorless crystals or white crystalline solid. Aromatic penetrating slightly acrid odor and a slightly bitter caustic taste.
Uses
Therap cat: sedative, hypnotic.

Registry Numbers and Inventories.
CAS
302-17-0
EC (EINECS/ELINCS)
206-117-5
EC Index Number
605-014-00-6
EC Class
Toxic; Irritant
R 25 36/38
RTECS
FM8750000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
12,2113
Beilstein/Gmelin
1698497
Beilstein Reference
4-01-00-03143
EPA OPP
268100
Swiss Giftliste 1
G-1384
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2H3Cl3O2
Formula mass
165.40
Boiling point, °C
97.5
Vapor pressure, mmHg
26 (25 C)
Vapor density (air=1)
5.1
Density
1.901 g/cm3
Solubility in water
Very soluble
Viscosity
16.72 cp (50 C)
pKa/pKb
10.54 (pKa)
Partition coefficient, pKow
1.68
Heat of fusion
22.9 kJ/mol
Heat of vaporization
39.2 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light. Store under an inert atmosphere.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Store protected from light. Handle under an inert atmosphere. Store protected from air. Wash clothing before reuse. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere. Do not get water inside containers.
Stability
Air sensitive Moisture sensitive. Sensitive to Light.
Incompatibilities
Alkalis, alkaline earth metals, alkali carbonates, soluble barbiturates, borax, tannin, iodides, permanganates, alcohols, strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
57
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
Chronic inhalation may cause effects similar to those of acute inhalation. Can be addictive. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Experimental carcinogen.
   Ingestion
Harmful if swallowed. Symptoms may include: headache, excitement, fatigue, nausea, vomiting, stupor, and coma. May cause central nervous system depression.
   Inhalation
Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Causes irritation of mucous membrane. Causes respiratory tract irritation with possible burns.
   Skin
Causes skin irritation and possible burns.
   Eyes
Causes severe eye irritation and possible injury.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2905 59 99