Chloramphenicol

  • Amphenicol
  • Amseclor
  • Chlomycol
  • D-Chloramphenicol
  • D-Threo-Chloramphenicol
  • Chloramsaar
Formula
C11H12Cl2N2O5
Structure
Description
Pale yellow plates or needles from water. White/gray/yellow powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
56-75-7
EC (EINECS/ELINCS)
200-287-4
S 22 36/37
RTECS
AB6825000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
UN (DOT)
1851
Merck
13,2087
Beilstein/Gmelin
2225532
Beilstein Reference
4-13-00-02742
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C11H12Cl2N2O5
Formula mass
323.13
Melting point, °C
150
Boiling point, °C
645
Vapor pressure, mmHg
2E-17 (25 C)
Vapor density (air=1)
11.1
Density
1.49 g/cm3
Solubility in water
2.5 g/L (25 C)
Refractive index
1.5403 (164 C)
pKa/pKb
11.03 (pKa)
Partition coefficient, pKow
1.02
Heat of vaporization
100.0 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Store protected from light.
Handling
Wash hands before eating. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Acids, acid chlorides, acid anhydrides and oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
344
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
I-2A, N-2, CP65
Exposure effects
May cause cancer in humans.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause hemorrhaging of the digestive tract. Exposure may cause anemia and other blood abnormalities.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.
UN number
1851
Response guide