Chloroacetaldehyde

  • 2-Chloro-1-ethanal
  • Chloroethanal
Formula
ClCH2CHO
Structure
Description
A clear colorless liquid with a pungent odor.
Uses
Chemical int.

Registry Numbers and Inventories.
CAS
107-20-0
EC (EINECS/ELINCS)
203-472-8
EC Index Number
605-025-00-6
EC Class
Carcinogenic Category 3; Very toxic; Toxic; Corrosive; Dangerous for the Environment
R 24/25 26 34 40 50
S 26 28 36/37/39 45 61
RTECS
AB2450000
RTECS class
Mutagen
UN (DOT)
2232
Merck
13,2126
Beilstein/Gmelin
1071226
Beilstein Reference
4-01-00-03134
RCRA
P023
Swiss Giftliste 1
G-1378
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2H3ClO
Formula mass
78.5
Melting point, °C
-16.1
Boiling point, °C
85
Vapor pressure, mmHg
70 (25 C)
Vapor density (air=1)
2.7
Odor Threshold Odor threshold 3.0 mg/m3
Density
1.236 g/cm3 (23 C)
Solubility in water
Miscible
Refractive index
1.4195 (35 C)
Partition coefficient, pKow
0.36
Heat of vaporization
32.5 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Apply water spray or mist to knock down vapors. Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.
Stability
The anhydrous substance polymerizes on standing, but reverts to the monomer on distillation.
Incompatibilities
Sensitive to heat Reacts with oxidizing agents Incompatible with acids and water.

Fire.
Flash Point,°C
-11
Upper exp. limit, %
18.4
Lower exp. limit, %
5.7
Fire fighting
Do not fight fires in a cargo of explosives. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.
Fire potential
Flammable.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Contain poisonous and irritating chloride gases.

Health.
Exposure limit(s)
TLV: 1 ppm; 3.2 mg/m3 (as CEILING) (ACGIH 1997). OSHA PEL: C 1 ppm (3 mg/m3) NIOSH REL: C 1 ppm (3 mg/m3) NIOSH IDLH: 45 ppm
Poison_Class
2
Exposure effects
Rapid breathing may occur. Chloroacetaldehyde, as a metabolite, has been implicated in the neurotoxicity associated with ifosfamide treatment. No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
   Ingestion
Abdominal pain, burning sensation.
   Inhalation
Coughing, choking, bronchial constriction, and pulmonary edema may occur.
   Skin
Direct contact with skin may result in burns.
   Eyes
Ocular splash contact with strong solutions may result in tissue destruction and permanent vision loss. Low concentrations of vapors may be irritating to the nose, throat, and eyes.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2232
Response guide
Hazard class
6.1
PRTC
T
Packing Group
I
 
USCG CHRIS Code
CHO
 
Std. Transport #
4921402