Chloroacetyl isocyanate

  • 2-Chloroacetyl isocyanate
  • Acetic acid, chloro-, anhydride with isocyanic acid
  • socyanic acid, anhydride with chloroacetic acid
Formula
C3H2ClNO2
Structure
Description
Colorless liquid.

Registry Numbers and Inventories.
CAS
4461-30-7
EC (EINECS/ELINCS)
224-715-4
R 14 23 34 42
S 23 26 36/37/39 45
UN (DOT)
3080
Merck
13,2134
Beilstein/Gmelin
1904273
Canada DSL/NDSL
DSL

Properties.
Formula
C3H2ClNO2
Formula mass
119.50
Melting point, °C
72
Boiling point, °C
61 - 66 (45 torr)
Vapor density (air=1)
4.12
Density
1.4 g/cm3
Solubility in water
Soluble
Refractive index
1.458 (20 C)

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Corrosives area. Refrigerator (approx 4 C).
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Combines vigorously or explosively with water.
Incompatibilities
Moisture, strong acids, strong bases, strong oxidizing agents, strong reducing agents, water.
Decomposition
Hydrogen chloride, hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
61
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Combustible Liquid. May ignite or explode on contact with steam or moist air. Containers may explode when heated. Extinguishing media: Use dry sand or earth to smother fire. Use water spray to cool fire-exposed containers. Use carbon dioxide or dry chemical. DO NOT USE WATER! Contact professional fire-fighters immediately.
Health
3
 
Flammability
2
 
 
Reactivity
2
 

Health.
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause nausea and vomiting. May cause systemic effects.
   Inhalation
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Aspiration may lead to pulmonary edema. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Exposure to low and often even unmeasurable isocyanate concentration results in sensitization. May cause systemic effects. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
Causes skin burns. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. Organic isocyanates can cause local irritation and allergic reactions. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns. Lachrymator. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
   Eyes
Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
3080
Response guide