Chlorpropham

  • Isopropyl-n-(3-Chlorophenyl)carbamate
  • 1-Methylethyl (3-chlorophenyl)carbamate
  • Isopropyl 3-chlorocarbanilate
Formula
C10H12ClNO2
Structure
Description
Brown chunky solid.
Uses
Chlorpropham acts as highly selective preemergence & early postemergence herbicide, it effectively controls many annual grassy & broadleaf weeds, application during late fall & winter for control of some perennial weeds.

Registry Numbers and Inventories.
CAS
101-21-3
EC (EINECS/ELINCS)
202-925-7
RTECS
FD8050000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
2757
Merck
12,2240
Beilstein/Gmelin
2211397
Beilstein Reference
4-12-00-01149
EPA OPP
18301
Swiss Giftliste 1
G-1418
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C10H12ClNO2
Formula mass
213.66
Melting point, °C
41
Boiling point, °C
247
Vapor pressure, mmHg
0.02 (25 C)
Vapor density (air=1)
1.18
Density
1.1913 g/cm3 (20 C)
Solubility in water
108 ppm (20 C)
Refractive index
1.5388 (20 C)
pKa/pKb
10.99 (pKa)
Partition coefficient, pKow
3.68
Heat of vaporization
48.8 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Unlimited shelf life; not light or heat sensitive, but low temperature may cause crystallization of emulsifiable concentrate. Stable below 100 C, but slowly hydrolyzed in acidic or alkaline media.
Incompatibilities
Incompatible with strong acids and bases, and especially

Fire.
Flash Point,°C
105
Fire fighting
Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
Non-Combustible
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
4
Exposure effects
Exposure to thiram or mbdt-carb (based on animal studies) may cause weakness, ataxia, ascending paralysis and hypothermia. Peripheral neuropathy (pain, numbness and weakness of the extremities) has been noted following exposure to thiuram (the ethyl analog of thiram). No adverse reproductive effects (testicular parameters) in male mice were observed following methyl thiophanate doses up to 1000 mg/kg orally for 5 consecutive days (Traina et al, 1998). Maternal toxicity was evident in female rats.
   Ingestion
Nausea, vomiting and diarrhea may occur.
   Inhalation
Respiratory failure, requiring ventilatory support, has been reported following ingestions.
   Skin
Exposure to dusts, sprays, solutions, wettable powder suspensions or emulsions of these agents may lead to skin and mucous membrane irritation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2757
Response guide
Hazard class
6.1
Packing Group
I; II; III