Chlorthalidone

  • Demi-Regroton
  • Natriuran
  • 3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine
  • 2-Chloro-5-(3-hydroxy-1-oxoisoindol-3-yl)benzenesulfonamide
  • 1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
  • Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
Formula
C14H11ClN2O4S
Structure
Description
White to yellowish-white crystalline powder. Odorless.
Uses
Therap cat (vet): diuretic.

Registry Numbers and Inventories.
CAS
77-36-1
EC (EINECS/ELINCS)
201-022-5
RTECS
DB1556000
RTECS class
Reproductive Effector; Human Data
Merck
12,2246
Beilstein/Gmelin
312295
Beilstein Reference
5-22-07-00602
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C14H11ClN2O4S
Formula mass
338.77
Melting point, °C
179
Solubility in water
Slightly soluble
pKa/pKb
4.43 (pKb)

Hazards and Protection.
Storage
Keep in airtight container.
Handling
Use in hood. Wear protective equipment. Do not raise dust.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
None is normally required. If needed, a NIOSH/MSHA aproved air supplied respirator or dust respirator is advised.
Small spills/leaks
Wear approved protective equipment. Vacuum or sweep up spill. Avoid dust creation. Place spillage in appropriate container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Toxic fumes.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Irritation. Possible allergic reation to dust. May cause dryness of mouth, increased thirst, irregular heartbeat, mood changes, muscle cramps, pain, nausea, vomiting, tiredness, weakness, weak pulse.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.