Cinchonine

  • alpha-4-Quinolyl-5-vinyl-2-quinnuclidinemethanol
Formula
C19H22N2O
Structure
Description
Off-white crystals.
Uses
Antimalarial agent.

Registry Numbers and Inventories.
CAS
118-10-5
EC (EINECS/ELINCS)
204-234-6
S 22 36/37
RTECS
GD3500000
RTECS class
Drug; Natural Product
UN (DOT)
2811
Merck
13,2308
Beilstein/Gmelin
89689
Beilstein Reference
5-23-12-00406
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C19H22N2O
Formula mass
294.40
Melting point, °C
261 - 264
Density
1.2 g/cm3
Solubility in water
Insoluble

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Handling
Wash hands before eating. Use only in a well ventilated area. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Store protected from light. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
3 (Strong toxins)
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Tinnitus, dizziness, rash, cardiovascular effects, headache, fever, intestinal cramping, diarrhea, vomiting, apprehension, confusion, seizures are symptoms associated with the syndrome of cinchonism.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. In rare instances, exposure may cause sensitization, resulting in inflammation of the mucous membranes and in eczematous eruptions.
   Skin
May cause skin irritation. The toxicological properties of this material have not been fully investigated. Chronic exposure may result in sensitization.
   Eyes
May cause eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2939 29 00