- Cinerolonyl (+)-pyrethrate
Registry Numbers and Inventories.
EC Index Number
Harmful; Dangerous for the Environment
Boiling point, °C
182-184 (0.001 torr)
Solubility in water
1.5182 (17 C)
Hazards and Protection.
Pyrethrins with piperonyl butoxide topical preparations should be stored in well-closed containers at a temperature less than 40C, preferably between 15-30C.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate personal protective clothing to prevent skin contact. Pyrethrum.
Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure-mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Oxidizes rapidly and becomes inactive in presence of air. Pyrethrins are decomposed by exposure to light with loss of insecticidal activity. They are rapidly oxidized and inactivated by air. As the pyrethrins approach 100% purity, their stability decreases; pyrethrin i and ii are less stable than the other compounds. Pyrethrins synergists have a stabilizing effect.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
IDHL: 5000 mg/m3
Nausea, vomiting and abdominal pain commonly occur and develop within 10 to 60 minutes following ingestion.
Hypersensitivity reactions characterized by pneumonitis, cough, dyspnea, wheezing, chest pain, and bronchospasm may occur. Rare cases of respiratory failure and cardiopulmonary arrest have been reported.
Irritant and contact dermatitis may develop. Erythema which mimics sunburn has also been noted after prolonged repeated exposure.
There is no specific antidote for pyrethrin poisoning. Treatment is symptomatic and supportive and includes monitoring for the development of hypersensitivity reactions with respiratory distress. Provide adequate airway management when needed. Gastric decontamination is usually not required unless the pyrethrin product is combined with a hydrocarbon. Allergic reaction: mild: antihistamines with or without epinephrine. Severe: oxygen, aggressive airway management, antihistamines, epinephrine (adult: 0.3 To 0.5 Ml of a 1:1000 solution subcutaneously; child: 0.01 Ml/kg; may repeat in 20 to 30 min), corticosteroids, ecg monitoring, and iv fluids.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. Vitamin e topical application is highly effective in relieving paresthesias.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.