Clofazimine

  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
  • 2-p-Chloroanilino-5-p-chlorophenyl-3,5-dihydro-3-isopropyliminophenazine
  • 2-(4-Chloroanilino)-3-isopropylimino-5-(4-chlorophenyl)-3,5-dihydrophenazine
  • 3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
  • Lamprene
  • Hansepran
Formula
C27H22Cl2N4
Structure
Uses
An antibiotic which attacks the bacteria that cause leprosy.

Registry Numbers and Inventories.
CAS
2030-63-9
EC (EINECS/ELINCS)
217-980-2
RTECS
SG1578000
RTECS class
Drug; Mutagen
Merck
12,2433
Beilstein/Gmelin
60420
Beilstein Reference
4-25-00-03033
Austrailia AICS
Listed

Properties.
Formula
C27H22Cl2N4
Formula mass
473.4
Melting point, °C
210 (decomposes)
Vapor pressure, mmHg
7E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
7.76 (pKb)
Partition coefficient, pKow
5.39
Heat of vaporization
85.1 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful. Harmful if swallowed.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled.
   Skin
May be harmful if absorbed through the skin.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.