Clofibrate

  • Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
  • 2-(P-chlorophenoxy)-2-methylpropionic*acid ethyl
  • Phenoxyisobutyricacidethylester
  • Antilipid
  • Ateculon
  • Ateriosan
Formula
C12H15ClO3
Structure
Description
Oil. Faint characteristic odor.
Uses
Agent to lower plasma very-low-density-lipoprotein concn, agent to lower concn of plasma triglycerides.

Registry Numbers and Inventories.
CAS
637-07-0
EC (EINECS/ELINCS)
211-277-4
RTECS
UE9480000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,2436
Beilstein/Gmelin
1913459
Beilstein Reference
4-06-00-00851
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C12H15ClO3
Formula mass
242.7
Boiling point, °C
148
Density
1.138-1.144 g/cm3 (20 C)
Solubility in water
insoluble
Refractive index
1.505 (19 C)

Hazards and Protection.
Storage
Clofibrate liquid-filled capsules should be stored in well-closed, light-resistant containers, at a temperature less than 40C. Preferably at 15-30C; freezing of the liquid-filled capsules should be avoided.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Sensitive to oxidation and light; easily hydrolyzed.
Incompatibilities
Strong oxidizing agents.

Fire.
Flash Point,°C
110
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
CP65
Exposure effects
with therapeutic use - fatigue, weakness, drowsiness, dizziness, and headache have been reported during clofibrate therapy. Clofibrate and Fenofibrate are classified as FDA Pregnancy Category C.
   Ingestion
Ausea, vomiting, constipation, dyspepsia, diarrhea, and flatulence occur transiently in approximately 10% of patients. Epigastric pain has been reported as a frequent side effect and cholelithiasis is increased.
   Skin
Various rashes and alopecia have been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.