Clonidine

  • 2-((2,6-Dichlorophenyl)amino)-2-Imidazoline
  • Clonidin
  • 2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
  • 2-(2,6-Dichloroanilino)-2-Imidazoline
Formula
C9H9Cl2N3
Structure
Description
Crystals.
Uses
In shaving soaps and as an antihypertensive.

Registry Numbers and Inventories.
CAS
4205-90-7
EC (EINECS/ELINCS)
224-119-4
RTECS
NJ2487000
RTECS class
Drug; Reproductive Effector; Human Data; Primary Irritant
Merck
12,2450
Beilstein/Gmelin
746076
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H9Cl2N3
Formula mass
230.1
Melting point, °C
141 - 142
pKa/pKb
8.05 (pKa)
Partition coefficient, pKow
1.57

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in light, air, and heat.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Mild elevated blood pressure may develop early, and is usually followed by abnormally low blood pressure. Relative low heart rate is common although rapid heart rate may occur. Mild reduced body temperature and respiratory depression are common in patients with cns depression. lethargy and coma are frequently reported. Hypotonia and hyporeflexia may occur. Seizures may rarely occur.
   Ingestion
Intermittent apnea and respiratory depression are common, especially in children. Respiratory arrest may occur. Respiratory depression usually responds to tactile stimulation.
   Inhalation
Intermittent apnea and respiratory depression are common, especially in children. Respiratory arrest may occur. Respiratory depression usually responds to tactile stimulation.
   Skin
Pallor and cool skin may develop.
   Eyes
Constriction of the pupil occurs in over 50% of cases.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.