Clozapine

  • Clozaril
  • Azaleptine
  • Clorazil
  • Leponex
  • Iprox
  • 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Formula
C18H19ClN4
Structure
Description
Yellow crystals from acetone-petroleum ether.
Uses
Atypical antipsychotic compound. Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7serotonin receptors.

Registry Numbers and Inventories.
CAS
5786-21-0
EC (EINECS/ELINCS)
227-313-7
22 36/37/38
RTECS
HP1750000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,2484
Beilstein/Gmelin
764984
Beilstein Reference
5-25-11-00364
New Zealand
Listed

Properties.
Formula
C18H19ClN4
Formula mass
326.83
Melting point, °C
182
Boiling point, °C
489
Vapor pressure, mmHg
1E-9 (25 C)
Solubility in water
Insoluble
pKa/pKb
7.67 (pKb)
Heat of vaporization
75.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents.

Fire.
Flash Point,°C
250
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
   Ingestion
Harmful if swallowed.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.