Cocculus

  • Picrotoxin
Formula
C30H34O13
Structure
Description
Shiny rhomboid leaflets. Odorless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
124-87-8
EC (EINECS/ELINCS)
204-716-6
RTECS
TJ9100000
RTECS class
Drug; Human Data; Natural Product
UN (DOT)
1584
Merck
12,7570
Beilstein/Gmelin
3894406
Beilstein Reference
4-19-00-05245
EPA OPP
2301

Properties.
Formula
C15H18O7*C15H16O6
Formula mass
602.59
Melting point, °C
199 - 200
Solubility in water
Soluble in hot water

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. May decompose when exposed to light.
Incompatibilities
Strong oxidizing agents - strong acids - strong bases - light.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-Combustible
Hazards
When heated to decomposition it emits acrid smoke and fumes. Avoid decomposing heat.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Slowing of pulse followed by increase pulse rate has been reported. Elevated body temperature has been reported in one case and reduced body temperature has developed in animals. Elevated blood pressure and rapid breathing have been reported. CNS stimulation including excitement, somnolence, anorexia, hyperpyrexia, sweating, muscle rigidity, hyperactivity, delirium, hallucinations, seizures, coma, and respiratory failure may be seen. All parts of the CNS are affected. Clonic/tonic seizures have been seen in animals given lethal doses. Behavioral changes have been seen in animals. No data were available to assess the teratogenic potential of this agent. <br>No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
   Ingestion
May cause irritation of the digestive tract. May cause central nervous system effects.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1584
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
PCX