Colchicine

  • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-(S)
  • N-Acetyl trimethylcolchicinic acid methyl ether
  • Benzo[a]heptalen-9(5H)-one
  • 7-alpha-H-Colchicine
  • Colchineos
  • n-(5,6,7,9-Tetrahydro-1,2,3,10-Tetramethoxy-9-oxobenzo
Formula
C22H25NO6
Structure
Description
Pale yellow scales or powder; pale yellow needles when crystallized from odorless or nearly so.
Uses
In research in plant genetics (for doubling chromosomes).

Registry Numbers and Inventories.
CAS
64-86-8
EC (EINECS/ELINCS)
200-598-5
EC Index Number
614-005-00-6
EC Class
Very toxic
RTECS
GH0700000
RTECS class
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2811
Merck
12,2536
Beilstein/Gmelin
2228813
Beilstein Reference
4-14-00-00946
Swiss Giftliste 1
G-1439
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C22H25NO6
Formula mass
399.44
Melting point, °C
154 - 156
Vapor density (air=1)
14
Density
1.32 g/cm3
Solubility in water
50 g/L

Hazards and Protection.
Storage
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Slight fire hazard.
Hazards
Stable.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
1*
Exposure effects
May cause bone marrow abnormalities with damage to blood forming tissues.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause systemic toxicity with acidosis. Exposure may cause anemia and other blood abnormalities. May produce aplastic anemia, blood pressure depression, body temperature decrease, changes in kidnet tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea, vomiting, respiratory stimulation and somnolence. Prolonged ingestion may produce bone marrow depression with agranulocytosis, thrombocytopenia, leukopenia and aplastic anemia may occur with prolonged administration. Lab findings in overdoses have indicated metabolic acidosis, hyponatremia, hypokalemia, bone marrow hypoplasia, thrombocytopenia, granulocytopenia, coagulopathy, and less commonly hemolytic anemia.
   Inhalation
Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.
   Skin
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
CLI