- O-(4-Nitrophenyl) O-phenyl methylphosphonothioate
- O-(p-Nitrophenyl) O-phenyl methylphosphonothioate
- O-(p-Nitrophenyl)-O-phenyl methylphosphonothionate
- Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester
- Phosphonothioic acid, methyl-, O-(p-nitrophenyl) O-phenyl ester
- Colep; CP 40294
Broad spectrum insecticide (product has not been marketed).
Registry Numbers and Inventories.
Agricultural Chemical and Pesticide
Melting point, °C
Solubility in water
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Workers handling and applying organophosphate pesticides must be given personal protective equipment comprising overalls made of a tight fabric or polyvinyl chloride, gloves, and rubber boots. The eyes should be protected by goggles. Wear appropriate chemical protective gloves, boots and goggles. Wear appropriate chemical protective clothing. If contact with the material anticipated, wear appropriate chemical protective clothing.
Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure.<BR>Wear a respirator with an activated-carbon gas filter cartridge affording protection for a determined number of working hours.
Caution : Chemical structure indicates that this is an organic phosphorus pesticide. (Non-Specific -- Organic Phosphorus Insecticides) Do not touch spilled material; stop leak if possible. Use water spray to reduce vapors. Absorb spills with noncombustible absorbent material. For large spills dike far ahead for later disposal.
(Non-Specific -- Organophosphorus Pesticide) Stay upwind; keep out of low areas. Move containers from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.(Non-Specific -- Organophosphorus Pesticide) This material may burn, but does not ignite readily. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam.
Combustible material: may burn but does not ignite readily.
Containers may explode when heated.
When heated to decomp, can emit highly toxic fumes of oxides of phosphorous.
Fever, low heart rate and abnormally low blood pressure, or rapid heart rate and elevated blood pressure may occur. Headache, dizziness, muscle spasms and profound weakness are common. Alterations of level of consciousness, anxiety, paralysis, seizures and coma may occur. Seizures may be more common in children.
Vomiting, diarrhea, fecal incontinence, and abdominal pain may occur.
Dyspnea, rales, bronchorrhea, or tachypnea may be noted. Pulmonary edema may occur in severe cases.
Sweating is a consistent but not universal sign.
Constriction of the pupil, tearing, and blurred vision are common. Prolonged dialation of the pupils may occur in severe poisonings. Opsoclonus has occurred rarely. Excessive salivation commonly occurs.
Seek medical assistance.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Systemic effects can occur from dermal exposure to organophosphates. Remove contaminated clothing, wash skin, hair and nails vigorously with repeated soap washings. Leather absorbs pesticides; all contaminated leather should be discarded. Rescue personnel and bystanders should avoid direct contact with contaminated skin, clothing, or other objects. Treatment should include recommendations listed in the oral exposure section when appropriate. Some chemicals can produce systemic poisoning by absorption through intact skin. Carefully observe patients with dermal exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary. Contraindications - succinylcholine and other cholinergic agents are contraindicated.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved. Suction oral secretions until atropinization. Treatment should include recommendations listed in the oral exposure section when appropriate. Contraindications - succinylcholine and other cholinergic agents are contraindicated.
I; II; III