Corticosterone

  • Kendall's Compound B
  • 11b,21-Dihydroxyprogesterone
  • 4-Pregnene-11b,21-diol-3,20-dione
  • 11b,21-Dihydroxy-4-pregnene-3,20-dione
Formula
C21H30O4
Structure
Uses
Glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Registry Numbers and Inventories.
CAS
50-22-6
EC (EINECS/ELINCS)
200-019-6
RTECS
GM7650000
RTECS class
Drug; Mutagen; Reproductive Effector
Merck
12,2601
Beilstein/Gmelin
2339601
Beilstein Reference
4-08-00-02907
Korea ECL
Listed

Properties.
Formula
C21H30O4
Formula mass
346.47
Melting point, °C
178 - 180
Boiling point, °C
529
Vapor pressure, mmHg
2E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
12.96 (pKa)
Heat of vaporization
92.5 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dark location. Keep tightly closed.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable under normal storage temperatures and pressures. Light sensitive material.
Incompatibilities
Oxidizing agents.
Decomposition
Oxides of carbon.

Fire.
Flash Point,°C
288
Fire fighting
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Use water spray, carbon dioxide, dry chemical powder, or appropriate foam to distinguish fire.
Combustion products
Emits toxic fumes under fire conditions.
Health
3
 
Flammability
0
 
 
Reactivity
1
 

Health.
Exposure effects
Some steroids show carcinogenic and/or teratogenic activity.
   Ingestion
May be harmful if swallowed. Can cause nausea, dizziness and headache.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract. Can cause nausea, dizziness and headache.
   Skin
May casues skin irritation. Harmful if absorbed through the skin.
   Eyes
May cause irritation

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.