Cromolyn

  • 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane
  • Cromoglicic acid
  • 5,5'-(2-Hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid)
  • 1,3-di(2-Carboxy-4-oxochromen-5-yloxy)propan-2-ol
Formula
C23H16O11
Structure
Description
Colorless crystals from ethanol + ether.
Uses
Medication.

Registry Numbers and Inventories.
CAS
16110-51-3
EC (EINECS/ELINCS)
240-279-8
RTECS
DJ2365000
RTECS class
Drug
Merck
12,2658
Beilstein/Gmelin
1336926
Austrailia AICS
Listed

Properties.
Formula
C23H16O11
Formula mass
468.37
Melting point, °C
242 - 247
pKa/pKb
1.10 (pKa)
Partition coefficient, pKow
-0.48

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
STORAGE PRECAUTIONS: You should store this material in a refrigerator.
Stability
Very stable with no degradation under normal storage conditions except for moisture gain.
Incompatibilities
Reacts in this way with all bases, both organic (for example, the amines) and inorganic Can react with active metals to form gaseous hydrogen and a metal salt.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
with therapeutic use - drowsiness has occurred with the use of cromolyn nebulizer solution. Headache (1 in 50 patients) has been seen with cromolyn sodium nasal solution. Dizziness and headache have been reported after use of of the capsules for inhalation. Peripheral neuritis is seen infrequently. It is unknown whether cromolyn is excreted in breast milk. <br>Cromolyn is listed as a Pregnancy Category B risk. No well controlled clinical studies have been done in humans.
   Ingestion
Ausea and stomachache have been seen with the use of cromolyn sodium capsules for inhalation.
   Inhalation
Bronchial irritation may be seen with cromolyn use, and pulmonary infiltrates have been reported in two cases. A number of asthmatic attacks have occurred in patients using cromolyn.
   Skin
Urticaria, eczema, and contact dermatitis have been reported after therapeutic administration.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.