Cycloheximide

  • 4-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)
  • 2,6-Piperidinedione
Formula
C15H23NO4
Structure
Description
Colorless crystals.
Uses
Used to kill fungus.

Registry Numbers and Inventories.
CAS
66-81-9
EC (EINECS/ELINCS)
200-636-0
EC Index Number
613-140-00-8
EC Class
Mutagenic Category 3; Toxic for reproduction Category 2; Very toxic; Dangerous for the Environment
RTECS
MA4375000
RTECS class
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2588
Merck
12,2797
Beilstein/Gmelin
88868
Beilstein Reference
5-21-13-00434
EPA OPP
43401
Swiss Giftliste 1
G-1460
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C15H23NO4
Formula mass
281.35
Melting point, °C
119.5 - 121
Boiling point, °C
358
Vapor density (air=1)
9.7
Critical temperature
609
Critical pressure
56.7
Solubility in water
21 g/L
Partition coefficient, pKow
-0.62

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get on skin or in eyes. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases, acid chlorides, acid anhydrides.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire potential
Non-Combustible
Hazards
When exposed to heat, it emits toxic fumes, including nitrogen oxides.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
1
Exposure effects
Repeated exposure may cause sensitization dermatitis. May cause reproductive and fetal effects.
   Ingestion
May be fatal if swallowed. Poison by ingestion. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. May cause effects similar to those described for ingestion.
   Skin
Causes severe skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2588
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
CXI