Cyclophosphamide monohydrate

  • 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate
  • 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridine monohydrate
Formula
C7H15Cl2N2O2P.H2O
Structure
Description
Fine white crystalline powder with a slightly bitter taste. Little or no odor.
Uses
Proposed as defleecing agent for sheep.

Registry Numbers and Inventories.
CAS
6055-19-2
EC (EINECS/ELINCS)
200-015-4
R 45 46 61 25
RTECS
RP6157750
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
2811
Merck
13,2776
Beilstein/Gmelin
9202500
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C7H15Cl2N2O2P.H2O
Formula mass
279.10
Melting point, °C
49-53

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Keep under an argon blanket.
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases.
Decomposition
Hydrogen chloride, nitrogen oxides, phosphine, carbon monoxide, oxides of phosphorus, carbon dioxide.

Fire.
Flash Point,°C
> 112
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This chemical is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-1, CP65
Exposure effects
May cause cancer in humans.
   Ingestion
May cause irritation of the digestive tract. Poison by ingestion. May cause nausea and vomiting.
   Inhalation
May cause respiratory tract irritation. May be harmful if inhaled. May cause nausea and possible vomiting.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation. Causes redness and pain.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III