Cyclophosphamide

  • 2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide
  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
Formula
C7H15Cl2N2O2P
Structure
Description
Fine white crystalline powder. Odorless with a slightly bitter taste.
Uses
Medication.

Registry Numbers and Inventories.
CAS
50-18-0
EC (EINECS/ELINCS)
200-015-4
RTECS
RP5950000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
1851
Merck
12,2816
Beilstein/Gmelin
11744
Beilstein Reference
4-27-00-09750
RCRA
U058
Austrailia AICS
Listed

Properties.
Formula
C7H15Cl2N2O2P
Formula mass
261.09
Melting point, °C
65 - 66
Boiling point, °C
336
Vapor pressure, mmHg
0.0001 (25 C)
Density
1.479 g/cm3
Solubility in water
40 g/L
pKa/pKb
9.91 (pKb)
Partition coefficient, pKow
0.63
Heat of vaporization
57.9 kJ/mol

Hazards and Protection.
Storage
Preserve in tight containers between 2 and 32 C.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Aq solution keeps for a few hr @ room temperature, but hydrolysis occurs above 30 C, removes chlorine atoms; darkens on exposure to light monohydrate sensitive to oxidation, moisture. Monohydrate.
Incompatibilities
Sensitive to exposure to light (darkens) Sensitive to oxidation Incompatible with benzyl alcohol.

Fire.
Flash Point,°C
157
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Carcinogin
I-1, N-1, CP65
Exposure effects
Agitation, dizziness, tiredness, weakness, and headache may occur. Not recommended in pregnancy or breast-feeding.
   Ingestion
Nausea, vomiting, diarrhea, stomatitis, and hemorrhagic colitis have been reported.
   Inhalation
Pneumonitis or interstitial pulmonary fibrosis may occur.
   Skin
Extravasation does not produce a local reaction. Alopecia, pigmentation of finger nails and skin may occur.
   Eyes
Flushing of the face may occur. Swollen lips may be noted.

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1851
Response guide
USCG CHRIS Code
CYM