Cyclothiazide

  • Anhydron
  • Aquirel
  • Renazide
  • Doburil
  • MDi-193
  • 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Formula
C14H16ClN3O4S2
Structure
Description
white solid
Uses
Major uses include therap cat: diuretic, antihypertensive. Blocks the rapid desensitization of the AMPA receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

Registry Numbers and Inventories.
CAS
2259-96-3
EC (EINECS/ELINCS)
218-859-7
36/37/38
RTECS
DK9610000
RTECS class
Drug
Merck
12,2822
Beilstein/Gmelin
722843
Beilstein Reference
6-27

Properties.
Formula
C14H16ClN3O4S2
Formula mass
389.88
Melting point, °C
226 - 228
Boiling point, °C
627
Vapor pressure, mmHg
1E-15 (25 C)
Solubility in water
Insoluble
pKa/pKb
8.73 (pKa)
Heat of vaporization
92.8 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
333
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
   Ingestion
May be harmful if swallowed.
   Inhalation
Material is irritating to mucous membranes and upper
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.