Cytarabine hydrochloride

  • Cytosine, 1-beta-D-arabinofuranosyl, monohydrochloride
Formula
C9H13N3O5 . HCl
Structure
Description
Crystals (from aqueous ethanol) or fluffy white powder.
Uses
Treatment of leukaemia, especially acute non-lymphoblastic leukaemia

Registry Numbers and Inventories.
CAS
69-74-9
EC (EINECS/ELINCS)
200-713-9
RTECS
HA5500000
RTECS class
Drug; Mutagen; Reproductive Effector; Primary Irritant
Beilstein/Gmelin
4045072
Korea ECL
Listed

Properties.
Formula
C9H13N3O5.ClH
Formula mass
279.68
Melting point, °C
210 - 212

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Repeated exposure may cause sensitization dermatitis. Reproductive effects have been reported in animals.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause bone marrow depression.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause dermatitis.
   Eyes
Causes mild eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.