Cytarabine

  • U-19920 a
  • U-19,920
  • AC-1075
  • Alexan
  • 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
  • Ara-C
Formula
C9H13N3O5
Structure
Description
White to off white, lyophilized powder. Odorless.
Uses
antileukemic agent

Registry Numbers and Inventories.
CAS
147-94-4
EC (EINECS/ELINCS)
205-705-9
RTECS
HA5425000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,2853
Beilstein/Gmelin
89175
Beilstein Reference
4-25-00-03669
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H13N3O5
Formula mass
243.22
Melting point, °C
223 - 224
Solubility in water
Soluble.
Partition coefficient, pKow
-2.18

Hazards and Protection.
Storage
Store in a tightly closed container in a cool area.
Handling
Avoid all fors of unprotected contact when mixing and administering this product.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator.
Stability
Stable.
Incompatibilities
Strong oxidizing agents.
Decomposition
Emits toxic fumes when heated.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
with therapeutic use - CNS toxicity is associated with high dose cytarabine therapy, and includes cerebral and cerebellar dysfunction. Peripheral neuropathy may develop. Teratogenicity has been reported in animal studies.
   Ingestion
Poisonous.
   Inhalation
Adult respiratory distress syndrome has been reported. Causes irritation. Poisonous.
   Skin
Rash is a common adverse effect of cytarabine therapy. Poisonous on contact.
   Eyes
Irritation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.