cis-Dichlorodiammineplatinum(II)

  • Cisplatin
  • Diamminedichloroplatinum
  • cis-Platinous diaminodichloride
Formula
Cl2H6N2Pt
Structure
Description
An anticancer drug. Orange-yellow to deep yellow solid or powder.
Uses
Medication: antineoplastic agent.

Registry Numbers and Inventories.
CAS
15663-27-1
EC (EINECS/ELINCS)
239-733-8
R 45 23/24/25
RTECS
TP2450000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
13,2341
Beilstein/Gmelin
2519 (G)
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
Cl2H6N2Pt
Formula mass
300.05
Decomposition point, °C
270
Density
3.738 g/m3
Solubility in water
Soluble

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes. Do not breathe dust.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, ammonia.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Toxic gases and vapors (such as chlorine) may be released when chlorine-containing soluble platinum salts decompose.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: TWA 1 mg/m3
Carcinogin
I-2A, N-2, CP65
Exposure effects
Effects may be delayed. Chronic exposure may cause reproductive disorders and teratogenic effects. This is an experimental neoplastigen, tumorigen, and carcinogen. Reproductive effects have been reported in humans. Potential cancer hazard.
   Ingestion
May be fatal if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause systemic effects. May cause kidney and liver damage. Causes hearing effects (decrease in hearing). May cause nausea and vomiting. May cause damage to peripheral nervous system. May cause anaphylaxis in some individuals.
   Inhalation
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. May cause sneezing, runny nose, cough, and asthma. May cause anaphyla xis in some individuals. Symptoms may be similar to those described f or ingestion.
   Skin
Causes skin burns. May be absorbed through the skin. May cause severe dermatitis and urticaria(hives). May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns. Lachrymator. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III