D-b-Acetylthioisobutyric acid

  • D-3-Acetylthio-2-methylpropionic acid
  • (S)-3-(Acetylthio)-2-methylpropanoic acid
  • (S)-3-Acetylthio-2-methylpropionic acid
Formula
CH3C(O)SCH2CH(CH3)COOH
Structure
Description
Clear, colorless solid.

Registry Numbers and Inventories.
CAS
76497-39-7
EC (EINECS/ELINCS)
278-480-8
Beilstein/Gmelin
4373328
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H10O3S
Formula mass
162.21
Melting point, °C
131 - 132
Boiling point, °C
277
Vapor pressure, mmHg
0.0013 (25 C)
Density
1.18 g/cm3 (20 C)
Solubility in water
Very soluble
Refractive index
1.4902 (20 C)
pKa/pKb
4.22 (pKa)
Partition coefficient, pKow
0.88
Heat of vaporization
56.7 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidants.
Decomposition
Irritating and toxic fumes and gases.

Fire.
Flash Point,°C
162
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May be fatal if inhaled. Harmful if inhaled. May cause respiratory tract irritation.
   Skin
May cause skin irritation. Harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Treat symptomatically and supportively. Get medical aid immediately. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
HS Code
2930 90 70