DL-Aminoglutethimide

  • 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
  • p-Aminoglutethimide
  • 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione
  • Ba-16038
  • Cytadren
  • Elipten
Formula
C13H16N2O2
Structure
Description
almost white powder
Uses
Derivative of the sedative glutethimide. Originally introduced as an anticonvulsant.

Registry Numbers and Inventories.
CAS
125-84-8
EC (EINECS/ELINCS)
204-756-4
36/37/38
RTECS
MA4026950
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,460
Beilstein/Gmelin
210656
Beilstein Reference
5-22-13-00297
Austrailia AICS
Listed

Properties.
Formula
C13H16N2O2
Formula mass
232.28
Melting point, °C
149 - 150
Boiling point, °C
457
Vapor pressure, mmHg
2E-8 (25 C)
Solubility in water
Insoluble
pKa/pKb
9.59 (pKb)
Heat of vaporization
71.8 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
230
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Irritant. Irritating to eyes, respiratory system and skin. Calif. Prop. 65 reproductive hazard. Target organ(s): Adrenal cortex. Thyroid.
   Ingestion
May be harmful if swallowed.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.