Dacarbazine

  • DIR
  • (Dimethyltriazeno)imidazolecarboxamide
  • 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
  • 4-(Dimethyltriazeno)imidazole-5-carboxamide
  • 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-Carboxamide
  • 5-(3,3-dimethyltriazeno)imidazole-4-carboxamide
Formula
C6H10N6O
Structure
Description
White to ivory microcrystals or off-white crystalline solid.
Uses
cytostatic drug

Registry Numbers and Inventories.
CAS
4342-03-4
EC (EINECS/ELINCS)
224-396-1
RTECS
NI3950000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,2866
Beilstein/Gmelin
521487
Austrailia AICS
Listed

Properties.
Formula
C6H10N6O
Formula mass
182.19
Melting point, °C
250 - 255
pKa/pKb
9.58 (pKb)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
Handling
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
I-2B, N-2, CP65
Exposure effects
May cause cancer according to animal studies. Effects may be delayed. Chronic exposure may cause liver damage.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. Exposure may cause anemia and other blood abnormalities. May cause anemia, leukopenia, and thrombocytopenia.
   Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema. Exposure to thermodegradation products may cause influenza-like symptoms such as chills, headache, mild respiratory discomfort, shaking of the limbs, and high fever.
   Skin
Causes skin irritation. May cause erythema, and edema with crusting and scaling.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.