Dactinomycin

  • ACT D
  • Actinomycin D
  • Actinomycin I
  • Actinomycin X 1
  • Actinomycin C1
  • Actinomycin I1
Formula
C62H86N12O16
Structure
Description
Bright red crystalline powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
50-76-0
EC (EINECS/ELINCS)
200-063-6
RTECS
AU1575000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant
UN (DOT)
2811
Merck
12,2867
Beilstein/Gmelin
605235
New Zealand
Listed

Properties.
Formula
C62H86N12O16
Formula mass
1255.44
Melting point, °C
246 - 247
Solubility in water
1 g in 25 ml of @ 10 C
pKa/pKb
11.90 (pKa)
Partition coefficient, pKow
3.21 @ pH of 7.4

Hazards and Protection.
Storage
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Wash area with soap and water. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases, strong acids
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
241
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
4
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
CP65
Exposure effects
   Ingestion
May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause loss of hearing. May cause neuromuscular paralysis.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation may produce coughing, nausea, and pulmonary edema.
   Skin
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
May cause severe eye irritation. May cause eye injury.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III