Danazol

  • Danazol
  • Danocrine
  • Danol
  • 17b-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
  • Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17a)-
Formula
C22H27NO2
Structure
Uses
Weak androgen and anterior pituitary suppressant.

Registry Numbers and Inventories.
CAS
17230-88-5
EC (EINECS/ELINCS)
241-270-1
20/21/22 63
RTECS
TU4157070
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,2875
Beilstein/Gmelin
1088173
Beilstein Reference
5-27
Canada DSL/NDSL
DSL
Austrailia AICS
Listed

Properties.
Formula
C22H27NO2
Formula mass
337.46
Melting point, °C
225
Boiling point, °C
478
Vapor pressure, mmHg
6E-10 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.10 (pKa)
Heat of vaporization
78.2 kJ/mol

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
243
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful. Possible risk of harm to the unborn child. Harmful by inhalation, in contact with skin and if swallowed. Calif. Prop. 65 reproductive hazard. Target organ(s): Female reproductive system. Pituitary.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.