Daunomycin

  • Daunomycin, hydrochloride
  • Cerubidine
  • Daunoblastin
  • Daunomycin chlorohydrate
  • Daunorubicin hydrochloride
  • 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S,10S)-
Formula
C27H29NO10.ClH
Structure
Description
Orange-red powder.
Uses
A pharmacological active drug used for the treatment of acute leukemia.

Registry Numbers and Inventories.
CAS
20830-81-3
EC (EINECS/ELINCS)
245-723-4
RTECS
HB7878000
RTECS class
Drug; Mutagen
Beilstein/Gmelin
4229221
RCRA
U059
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C27H29NO10*ClH
Formula mass
564.03
Melting point, °C
189
Partition coefficient, pKow
9.94

Hazards and Protection.
Storage
Protect from light in tightly sealed container.
Handling
Use in Class II biological safety cabinet.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Wet spil - clean with a 5% bleach solution until colorless liqud results. Absorb on inert material and transfer to plastic bags for disposal. Wear protective equipment.
Stability
Stable.
Incompatibilities
Strong oxidizing agents.
Decomposition
NIOSH approved respirator during operations producing aerosols.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2B, CP65
Exposure effects
No effects have been reported.

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
DYN