(-)-Deguelin

  • (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-on
Formula
C23H22O6
Structure
Description
Yellow, free flowing powder.
Uses
Anti-cancer, chemoprotective agent.

Registry Numbers and Inventories.
CAS
522-17-8
22-24/25
RTECS
DX1500000
RTECS class
Other
Merck
12,2918
Beilstein/Gmelin
1334183
Beilstein Reference
5-19-10-00580

Properties.
Formula
C23H22O6
Formula mass
394.42
Melting point, °C
180 - 181
Boiling point, °C
560
Vapor pressure, mmHg
1E-12 (25 C)
Solubility in water
Insoluble
Heat of vaporization
84.3 kJ/mol

Hazards and Protection.
Storage
Store at -20 C. Keep in a tightly sealed container.
Protection
Wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles.
Respirators
Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended.
Small spills/leaks
Wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed.
Stability
This material is stable if stored as directed
Incompatibilities
None reported.

Fire.
Flash Point,°C
245
Fire fighting
Extinguish using carbondDioxide, dry chemical powder, polymer foam, water spray. Wear Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Combustion products
Carbon monoxide, carbon dioxide.

Health.
Exposure effects
The toxicological properties of this compound have not been fully investigated. May cause irritation. Exercise appropriate precautions to prevent opportunities for inhalation, and to prevent direct contact with skin and eyes. Symptoms of overexposure may include: tremors, convulsions, seizures, or respiratory changes. All uncharacterized chemicals should be treated as suspected toxins. Target Organs: Eyes, Respiratory system, Skin, Central nervous system

First aid
 
   Ingestion
Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call physician or poison control immediately.
   Inhalation
Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately.
   Skin
Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately.
   Eyes
Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately.

Transport.