Demecarium bromide

  • Frumtosnil
  • Humorsol
  • Tosmicil
  • Visumatic
  • Decamethylenebis(m-dimethylaminophenyl-N-methylcarbamate) dimethobromide
  • (m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis[methylcarbamate]
Formula
C32H52Br2N4O4
Structure
Uses
Medication.

Registry Numbers and Inventories.
CAS
56-94-0
EC (EINECS/ELINCS)
200-301-9
RTECS
BR3130000
RTECS class
Other
Merck
12,2936
Beilstein/Gmelin
3880925
Beilstein Reference
4-13-00-00968

Properties.
Formula
C32H52N4O4*2Br
Formula mass
716.6
Melting point, °C
164 - 170

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
   Ingestion
Nausea, vomiting, abdominal pain, diarrhea, or belching may be noted.
   Inhalation
Dyspnea, bronchospasm, tachypnea, increased bronchial secretions, and pulmonary edema may occur, especially in asthmatic patients.

First aid
 
   Ingestion
Induction of vomiting is usually not necessary due to spontaneous vomiting. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Bethanechol - for substantial ingestions of bethanechol, consider gastric lavage preceded by endotracheal intubation. Other agents - carbachol, acetylcholine, and pilocarpine are liquids, rapidly absorbed and probably not removed significantly by gastric emptying procedures. Atropine sulfate is the drug of choice. For significant muscarinic symptoms administer: adults - 2 to 4 mg iv, repeated every 3 to 60 minutes as needed to control symptoms, then prn for 24 to 48 hours. Child - 0.04 To 0.08 Mg/kg iv (up to 4 mg) repeated every 5 to 60 minutes as necessary. Epinephrine - may assist in overcoming severe cardiovascular or bronchoconstrictor responses (dose: 0.1 To 1.0 Mg sc).
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.