Desoximetasone

  • 9-Fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione
Formula
C22H29FO4
Structure
Uses
A topical steroid used to treat inflammation caused by a number of conditions such as allergic reactions, eczema, and psoriasis.

Registry Numbers and Inventories.
CAS
382-67-2
EC (EINECS/ELINCS)
206-845-3
20/21/22 36/37/38 40 43
22 26 36
RTECS
TU3834000
RTECS class
Reproductive Effector; Hormone
Merck
12,2975
Beilstein/Gmelin
2228097
Beilstein Reference
6-08

Properties.
Formula
C22H29FO4
Formula mass
376.47
Melting point, °C
217
Vapor pressure, mmHg
2E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
12.80 (pKa)
Heat of vaporization
92.9 kJ/mol

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Fire.
Flash Point,°C
276
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Health.
Exposure effects
Harmful. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by skin contact. Target organ(s): Pituitary. Poss
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.