Dextromethorphan

  • (+)-3-Methoxy-N-methylmorphinan
  • D-1,2,3,9,10,10a-Hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethanophenanthrene
Formula
C18H25NO
Structure
Description
White to slightly yellow crystalline powder with no odor.
Uses
Antitussive hydrobromide.

Registry Numbers and Inventories.
CAS
125-71-3
EC (EINECS/ELINCS)
204-752-2
RTECS
QD0194000
RTECS class
Drug; Human Data
Beilstein/Gmelin
88549
Beilstein Reference
4-21-00-01367
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C18H25NO
Formula mass
271.44
Melting point, °C
109 - 111
Solubility in water
Insoluble.

Hazards and Protection.
Storage
Store in a tightly sealed container. Keep in a cool, dry location.
Handling
Use only with adequate ventilation. Avoide contact and breathing dust.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH approved respirator.
Small spills/leaks
Wear approved protective equipment. Vacuum/sweep up. Avoid dust generation. Place material in appropriate container for disposal. Ventilate area and wash site.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Toxic fumes, nitrogen oxides.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Possible allergic reaction if inhaled, ingested and contact with the skin or eyes. Causes irritation. Hyperexcitability, dizziness, drowsiness, nausea, vomiting, stomach pain, confusion, unusual excitement, nervousness, restlessness, irritability.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.