Diatrizoate

  • Amidotrizoate
  • Amidotrizoic acid
  • 3,5-bis(Acetylamino)-2,4,6-triiodobenzoic acid
  • 3,5-Diacetamido-2,4,6-triiodobenzoic acid
  • Diatriazoate
  • Diatrizoic acid
Formula
C11H9I3N2O4
Structure
Description
White powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
117-96-4
EC (EINECS/ELINCS)
204-223-6
RTECS
DG5950000
RTECS class
Other
Beilstein/Gmelin
2225144
Beilstein Reference
4-14-00-01308
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C11H9I3N2O4
Formula mass
613.92
Melting point, °C
> 300
Solubility in water
Slightly soluble
Partition coefficient, pKow
3.48

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Should be protected from light.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
weakness and headache are often seen. Seizures, parkinsonism, paresthesias, and encephalopathy have been reported, but are uncommon. Specific abnormalities have not been identified. These compounds cross the placental barrier and are evenly distributed in the fetus. They are excreted in breast milk as well. Elevated iodine levels may be seen in the child.
   Ingestion
Nausea, vomiting, metallic taste, and diarrhea are complications of therapy.
   Inhalation
Pulmonary edema, difficulty breathing, and cough may be seen. Hypersensitivity reactions may produce swelling of the glottis, dyspnea, wheezing, and bronchospasm.
   Skin
Complications include flushing, sweating, pallor, urticaria, ioderma, epidermal necrolysis, and pain at the injection site.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Many of these substances are intended for parenteral use only. Those intended for enteral use are generally poorly absorbed. Gastrointestinal decontamination is rarely required.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.