Diazoxide

  • Dizoxide
  • Hyperstat
  • 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide
Formula
C8H7ClN2O2S
Structure
Description
white solid
Uses
Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic b-cells; antihypertensive.

Registry Numbers and Inventories.
CAS
364-98-7
EC (EINECS/ELINCS)
206-668-1
22 36/37/38
22 26 36
RTECS
DK8185000
RTECS class
Drug; Reproductive Effector
Merck
12,3051
Beilstein/Gmelin
523907
Beilstein Reference
6-27
Canada DSL/NDSL
DSL
Austrailia AICS
Listed

Properties.
Formula
C8H7ClN2O2S
Formula mass
230.67
Melting point, °C
330
Vapor pressure, mmHg
4E-6 (25 C)
Solubility in water
Slightly soluble
Heat of vaporization
63.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Flash Point,°C
186
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Harmful if swallowed. Irritating to eyes, respiratory system and skin. Possible sensitizer. Target organ(s): Vascular system. Pancreas.
   Ingestion
Harmful if swallowed.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.