- Lewisite 1
Colorless liquid when pure; impurities lead to colors ranging from violet faint odor of geranium.
Poison gas, skin blistering agent.
Registry Numbers and Inventories.
Organometallic; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Swiss Giftliste 1
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
Vapor density (air=1)
Odor Threshold Odor threshold 1.40X10-2 mg/L
1.8682 g/cm3 (20 C)
1.83 cp (20 C)
1.5888 (20 C)
Heat of vaporization
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate protective gloves, clothing and goggles.
Wear positive pressure self-contained breathing apparatus (SCBA).
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Decomposed by water and alkalies. Inactivated by bleaching powder.
Arsenical vesicant vapors are decomposed rapidly by high humidity. Limited solubility slows the rate of the hydrolysis of liquid agents.
When heated to decomposition it emits toxic fumes of hydrogen chloride and arsenic. Decomposed by water and alkalies. Inactivated by bleaching powder.
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Dry chemical, carbon dioxide, alcohol-resistant foam or water spray.
Combustible material: may burn but does not ignite readily.
Prolonged exposure of the cylinders to fire or heat may result in the violent rupturing and rocketing of the cylinders.
Fire may produce irritating, corrosive and/or toxic gases.
OSHA PEL: 1910.1018 TWA 0.010 mg/m3 NIOSH REL: Ca C 0.002 mg/m3 15-minute See Appendix A NIOSH IDLH: Potential occupational carcinogen 5 mg/m3 (as As)
There is NO solid scientific evidence supporting Lewisite to be either carcinogenic, mutagenic or teratogenic.
Nausea and vomiting and salivation may occur with exposure to lewisite.
Severe respiratory irritation leading to pulmonary edema and chemical pneumonitis may occur following acute exposure to lewisite.
Severe vesication and burns have occurred following liquid and vapor exposure to lewisite.
Tearing and burns or strong irritation occur to the eyes. A geranium-like odor may be apparent on the victim.
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Prompt decontamination is of utmost importance. Immediately wash skin and clothes with 5% solution of sodium hypochlorite or diluted liquid household bleach, within one minute if possible. Wash contaminated skin with soap and water afterwards. Topical 5% bal ointment or solution may decrease vesicant effects. Remove contaminated clothing and jewelry. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing. Treat dermal irritation or burns with standard topical therapy.
Immediately flush with running water for at least 20 minutes.
I; II; III