Dichloro-(2-chlorovinyl) arsine

  • Lewisite 1
Formula
ClCH=CHAsCl2
Structure
Description
Colorless liquid when pure; impurities lead to colors ranging from violet faint odor of geranium.
Uses
Poison gas, skin blistering agent.

Registry Numbers and Inventories.
CAS
541-25-3
RTECS
CH2975000
RTECS class
Organometallic; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2810
Merck
12,3112
Beilstein/Gmelin
1720917
Beilstein Reference
3-04-00-01811
RCRA
D004
Swiss Giftliste 1
G-5519
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C2H2AsCl3
Formula mass
207.32
Melting point, °C
-44.7
Boiling point, °C
190
Vapor pressure, mmHg
0.6
Vapor density (air=1)
7.1
Odor Threshold Odor threshold 1.40X10-2 mg/L
Density
1.8682 g/cm3 (20 C)
Viscosity
1.83 cp (20 C)
Refractive index
1.5888 (20 C)
Heat of vaporization
46.98 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
Decomposed by water and alkalies. Inactivated by bleaching powder.
Incompatibilities
Arsenical vesicant vapors are decomposed rapidly by high humidity. Limited solubility slows the rate of the hydrolysis of liquid agents.
Decomposition
When heated to decomposition it emits toxic fumes of hydrogen chloride and arsenic. Decomposed by water and alkalies. Inactivated by bleaching powder.

Fire.
Flash Point,°C
-13
Fire fighting
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Dry chemical, carbon dioxide, alcohol-resistant foam or water spray.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Prolonged exposure of the cylinders to fire or heat may result in the violent rupturing and rocketing of the cylinders.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure limit(s)
OSHA PEL: 1910.1018 TWA 0.010 mg/m3 NIOSH REL: Ca C 0.002 mg/m3 15-minute See Appendix A NIOSH IDLH: Potential occupational carcinogen 5 mg/m3 (as As)
Poison_Class
1
Exposure effects
There is NO solid scientific evidence supporting Lewisite to be either carcinogenic, mutagenic or teratogenic.
   Ingestion
Nausea and vomiting and salivation may occur with exposure to lewisite.
   Inhalation
Severe respiratory irritation leading to pulmonary edema and chemical pneumonitis may occur following acute exposure to lewisite.
   Skin
Severe vesication and burns have occurred following liquid and vapor exposure to lewisite.
   Eyes
Tearing and burns or strong irritation occur to the eyes. A geranium-like odor may be apparent on the victim.

First aid
 
   Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Prompt decontamination is of utmost importance. Immediately wash skin and clothes with 5% solution of sodium hypochlorite or diluted liquid household bleach, within one minute if possible. Wash contaminated skin with soap and water afterwards. Topical 5% bal ointment or solution may decrease vesicant effects. Remove contaminated clothing and jewelry. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing. Treat dermal irritation or burns with standard topical therapy.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III