Diethyl sulfate

  • Sulfuric acid, diethyl ester
Formula
(C2H5)2SO4
Structure
Description
Colorless, oily liquid, darkens with age, faint ethereal or peppermint odor.
Uses
Ethylating agent, as an accelerator in sulfation of ethylene, in some sulfonations.

Registry Numbers and Inventories.
CAS
64-67-5
EC (EINECS/ELINCS)
200-589-6
EC Index Number
016-027-00-6
EC Class
Carcinogenic Category 2; Mutagenic Category 2; Harmful; Corrosive
R 45 46 20/21/22 34
RTECS
WS7875000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
1594
Merck
13,3156
Beilstein/Gmelin
1209714
Beilstein Reference
4-01-00-01326
Swiss Giftliste 1
G-1503
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H10O4S
Formula mass
154.19
Melting point, °C
-25
Boiling point, °C
208
Vapor pressure, mmHg
0.32 (25 C)
Vapor density (air=1)
5.31
Saturation Concentration
250 ppm (0.02%) at 20 C (calculated)
Density
1.179 g/cm3 (20 C)
Solubility in water
Insoluble
Viscosity
1.79 cp @ 20C
Surface tension
34.61 g/s2 (13 C)
Refractive index
1.40037 (20 C)
Dipole moment
4.41 D (25 C)
Dielectric constant
16.2 (20 C)
Partition coefficient, pKow
1.14
Heat of vaporization
42.6 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling
Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Do not allow contact with water. Discard contaminated shoes. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not get water inside containers.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Decomposes when heated.
Incompatibilities
Moisture, potassium-tert-butoxide, iron + water, alkalies, nitric acid, aluminum, peroxides, strong bases, strong oxidizing agents, 2,7-dinitro-9-phenylphenanthridine + water.
Decomposition
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
78
Autoignition, °C
436
Upper exp. limit, %
12.2
Lower exp. limit, %
1.8
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Water or foam may cause frothing. Use water spray to cool fire-exposed containers. Do NOT get water inside containers.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Containers may explode when heated.
Combustion products
Highly toxic fumes contaning sulfur oxides may be generated along with thermal decomposition products such as ethyl ether and ethylene.
Health
3
 
Flammability
1
 
 
Reactivity
1
 

Health.
Carcinogin
I-2A, N-2, CP65
Poison_Class
1*
Exposure effects
May cause fetal effects. May cause cancer in humans. Effects may be delayed. Chronic exposure may cause lung damage. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause corneal erosion, conjunctivitis, and possible blindness.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. May cause systemic effects.
   Inhalation
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May be harmful if inhaled. May cause systemic effects.
   Skin
Harmful if absorbed through the skin. Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
1594
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
DSU
 
HS Code
2920 90 10
 
Std. Transport #
4933320
 
IMO Chemical Code
17
IMO Pollution Category
B
IMO Hazard code
S/P