Diethylcarbamazine citrate

  • 1-Methyl-4-diethylcarbamoylpiperazine citrate
  • Ethylaminoazine citrate
  • Dicarocide
  • Loxuran
  • N,N-Diethyl-4-methyl-1-piperazinecarboxamide dihydrogen citrate
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate
Formula
C10H21N3O.C6H8O7
Structure
Description
White crystalline powder, with slight odor to odorless, and slightly hygroscopic.
Uses
Medicine (anthelmintic).

Registry Numbers and Inventories.
CAS
1642-54-2
EC (EINECS/ELINCS)
216-696-6
RTECS
TL1225000
RTECS class
Drug; Reproductive Effector
Beilstein/Gmelin
3836352
Beilstein Reference
4-23-00-00225
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C10H21N3O*C6H8O7
Formula mass
391.48
Melting point, °C
137 - 139

Hazards and Protection.
Storage
Store in a cool, dry area away from heat and direct sunlight.
Handling
Wear suitable protective clothing, gloves and eye/face protection. Do not breathe dust.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear appropriate NIOSH/MSHA-approved respirator.
Small spills/leaks
Clean up personnel should wear full protective clothing including respiratory protection. Avoid raising dust. Sweep up spilled material and place in suitable container. Hold for later disposal. Ventilate and wash spill site after pickup complete.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Hazards
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. Exposure can cause nausea, headache and vomiting. Other symptoms may include anorexia, dizziness, joint pains, weakness and convulsions
   Inhalation
Harmful if inhaled. May cause irritation to the respiratory tract. Exposure can cause nausea, headaches and vomiting. Other symptoms include anorexia, dizziness, joint pains, weakness and convulsions.
   Skin
Harmful if absorbed through the skin. May cause irritation. Exposure can cause nausea, headache and vomiting.
   Eyes
Dust may cause irritation to the eyes.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person in conscious. Seek medical attention.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Follow recommendations under dermal exposure where appropriate.

Transport.
USCG CHRIS Code
DIZ