Diflunisal

  • 5-(2,4-Difluorophenyl)salicylic acid
  • Fluodonil
Formula
C13H8F2O3
Structure
Uses
Antiinflammatory drug.

Registry Numbers and Inventories.
CAS
22494-42-4
EC (EINECS/ELINCS)
245-034-9
22 36/37/38 63
22 26 36
RTECS
DV2030000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,3190
Beilstein/Gmelin
2654431
Beilstein Reference
6-10
Canada DSL/NDSL
DSL
Austrailia AICS
Listed

Properties.
Formula
C13H8F2O3
Formula mass
250.2
Melting point, °C
210 - 211
Boiling point, °C
390
Vapor pressure, mmHg
1E-6 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
2.94 (pKa)
Partition coefficient, pKow
4.24
Heat of fusion
35.8 kJ/mol
Heat of vaporization
67.1 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Fire.
Flash Point,°C
188
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful if swallowed. Irritating to eyes, respiratory system and skin. Possible risk of harm to the unborn child. Possible sensitizer. Target organ(s): Blood. Liver.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material is irritating to mucous membranes and upper respiratory tract.
   Skin
May be harmful if absorbed through the skin.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.