Difluprednate

  • 6a,9a-Difluoroprednisolone 21-acetate 17-butyrate
  • 6a,9-Difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate
Formula
C27H34F2O7
Structure
Uses
Steroidal anti-inflammatory medication.

Registry Numbers and Inventories.
CAS
23674-86-4
EC (EINECS/ELINCS)
245-815-4
RTECS
TU3831500
RTECS class
Reproductive Effector; Hormone
Merck
12,3194
Beilstein/Gmelin
2068618
Beilstein Reference
5-08

Properties.
Formula
C27H34F2O7
Formula mass
508.56
Melting point, °C
192 - 194
Vapor pressure, mmHg
6E-17 (25 C)
Solubility in water
Insoluble
pKa/pKb
12.62 (pKa)
Heat of vaporization
102.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Wear appropriate government approved respirator,
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.