- Diisopropyl phosphorofluoridate
Oily liquid. Clear, colorless or faintly yellow liquid.
Used in Germany as a basis for nerve gases.
Registry Numbers and Inventories.
Agricultural Chemical and Pesticide; Drug; Reproductive Effector; Human Data
Swiss Giftliste 1
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
1.1 (25 C)
Vapor density (air=1)
1.067 g/cm3 (19 C)
Solubility in water
1.32 cp (25 C)
1.381 (19.8 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Do not exceed 25-30C.
Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.
Stable under normal temperatures and pressures.
Strong bases - strong oxidizing agents, contact with moisture may generate hydrogen fluoride.
Phosphine, carbon monoxide, oxides of phosphorus, carbon dioxide, hydrogen fluoride.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For large fires, use water spray, fog, or alcohol-resistant foam. For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water may be ineffective.
Combustible material: may burn but does not ignite readily.
May burn but will not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Forms hydrogen fluoride in presence of moisture; decomposes in water at pH about 2.5. Keep away from sources of heat. Anhydrous compounds or oil solutions are stable in glass containers at room temperature.
Fire may produce irritating, corrosive and/or toxic gases.
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
May be fatal if swallowed. Diisopropyl fluorophosphate has the ability to induce neurotoxicity. It is manifested in as a severe polyneuritis that begins several days after exposure to a single or cumulative amount of the compound. It is manifested initially by mild sensory disturbances, ataxia, weakness, and weakness of the legs, accompanied by reduced tendon reflexes, and muscle twitching, fasciculation, and tenderness to palpation. In severe cases, the weakness may progress eventually to complete flaccid paralysis that, over the course of weeks and months is often accompanied by a spastic paralysis with a concomitant exaggeration of reflexes. During these phases, the muscles show marked wasting. Recovery may require 2 or more years.
Harmful if inhaled. Dust is irritating to the respiratory tract. Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Causes irritation of mucous membrane.
Causes skin irritation. May be absorbed through the skin in harmful amounts.
Causes eye irritation. A 12-month old boy who had received one drop of 0.1 DFP in each eye da ily for 2 months, experienced two briedf apneic spells, with probable seizure activity for 1 or 2 minutes each time...miotic, unreactive pup ils, profuse nasal discharge and possible motor weakness was noted. E ight hour after administration he had a typical grand mal convulsion l asting 2 to 3 minutes . Contact with the eyes may cause the developmen t of cataracts. It may also produce the following ocular side effects : headache, brow pain, blurred vision, phacodinesis, pericorneal injec tion, congestive iritis, various allergic reactions, and in rare cases retinal detachment.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
I; II; III
USCG CHRIS Code