Diisopropyl fluorophosphate

  • Diisopropyl phosphorofluoridate
  • Isofluorphate
Formula
C6H14FO3P
Structure
Description
Oily liquid. Clear, colorless or faintly yellow liquid.
Uses
Used in Germany as a basis for nerve gases.

Registry Numbers and Inventories.
CAS
55-91-4
EC (EINECS/ELINCS)
200-247-6
RTECS
TE5075000
RTECS class
Agricultural Chemical and Pesticide; Drug; Reproductive Effector; Human Data
UN (DOT)
2810
Merck
12,5192
Beilstein/Gmelin
1723307
Beilstein Reference
4-01-00-01480
RCRA
P043
EPA OPP
356100
Swiss Giftliste 1
G-1550
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C6H14FO3P
Formula mass
184.15
Melting point, °C
-82
Boiling point, °C
183
Vapor pressure, mmHg
1.1 (25 C)
Vapor density (air=1)
6.4
Density
1.067 g/cm3 (19 C)
Solubility in water
15.4 g/L
Viscosity
1.32 cp (25 C)
Refractive index
1.381 (19.8 C)
Partition coefficient, pKow
1.65
Heat of vaporization
40.2 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Do not exceed 25-30C.
Handling
Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong bases - strong oxidizing agents, contact with moisture may generate hydrogen fluoride.
Decomposition
Phosphine, carbon monoxide, oxides of phosphorus, carbon dioxide, hydrogen fluoride.

Fire.
Flash Point,°C
64
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For large fires, use water spray, fog, or alcohol-resistant foam. For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water may be ineffective.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
May burn but will not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Forms hydrogen fluoride in presence of moisture; decomposes in water at pH about 2.5. Keep away from sources of heat. Anhydrous compounds or oil solutions are stable in glass containers at room temperature.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
1
Exposure effects
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
   Ingestion
May be fatal if swallowed. Diisopropyl fluorophosphate has the ability to induce neurotoxicity. It is manifested in as a severe polyneuritis that begins several days after exposure to a single or cumulative amount of the compound. It is manifested initially by mild sensory disturbances, ataxia, weakness, and weakness of the legs, accompanied by reduced tendon reflexes, and muscle twitching, fasciculation, and tenderness to palpation. In severe cases, the weakness may progress eventually to complete flaccid paralysis that, over the course of weeks and months is often accompanied by a spastic paralysis with a concomitant exaggeration of reflexes. During these phases, the muscles show marked wasting. Recovery may require 2 or more years.
   Inhalation
Harmful if inhaled. Dust is irritating to the respiratory tract. Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Causes irritation of mucous membrane.
   Skin
Causes skin irritation. May be absorbed through the skin in harmful amounts.
   Eyes
Causes eye irritation. A 12-month old boy who had received one drop of 0.1 DFP in each eye da ily for 2 months, experienced two briedf apneic spells, with probable seizure activity for 1 or 2 minutes each time...miotic, unreactive pup ils, profuse nasal discharge and possible motor weakness was noted. E ight hour after administration he had a typical grand mal convulsion l asting 2 to 3 minutes . Contact with the eyes may cause the developmen t of cataracts. It may also produce the following ocular side effects : headache, brow pain, blurred vision, phacodinesis, pericorneal injec tion, congestive iritis, various allergic reactions, and in rare cases retinal detachment.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
DFP