Dimethyl acetamide

  • N,N-Dimethylacetamide
  • DMAC
  • Acetic acid dimethylamide
Formula
CH3CON(CH3)2
Structure
Description
Colorless liquid, weak ammonia or fish-like odor.
Uses
Solvent in industrial applications.

Registry Numbers and Inventories.
CAS
127-19-5
EC (EINECS/ELINCS)
204-826-4
EC Index Number
616-011-00-4
EC Class
Toxic for reproduction Category 2; Harmful
R 61 20/21
RTECS
AB7700000
RTECS class
Drug; Mutagen; Reproductive Effector; Primary Irritant
Merck
13,3254
Beilstein/Gmelin
1737614
Beilstein Reference
4-04-00-00180
Swiss Giftliste 1
G-1554
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H9NO
Formula mass
87.12
Melting point, °C
-20
Boiling point, °C
166.1
Vapor pressure, mmHg
10 (25 C)
Vapor density (air=1)
3
Saturation Concentration
2600 ppm (0.26%) at 25 C (calculated)
Evaporization number
172 (diethyl ether = 1), 0.138 (butyl acetate = 1)
Odor Threshold Odor threshold 20 ppm
Critical temperature
385
Critical pressure
39.7
Density
0.937 g/cm3 (20 C)
Solubility in water
Miscible
Viscosity
0.92 cp @ 25C
Surface tension
34 g/s2 @ 20 C
Refractive index
1.4373 (20 C)
Dipole moment
3.8 D (20 C)
Dielectric constant
37.8 (25 C)
Partition coefficient, pKow
-0.77
Heat of fusion
10.4 kJ/mol
Heat of vaporization
49.7 kJ/mol
Heat of combustion
-2540 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
B3 Combustible liquid. Class D2B Toxic Material; Chronic Toxic Effects.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Ammonia, nonoxidizing mineral acids, strong acids, phenols, isocyanates, cresol, halogens, coatings, plastics, rubber, iron.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
70
Autoignition, °C
354
Upper exp. limit, %
11.5
Lower exp. limit, %
1.7
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide.
Fire potential
This chemical is combustible.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 10 ppm (35 mg/m3) skin NIOSH REL: TWA 10 ppm (35 mg/m3) skin NIOSH IDLH: 300 ppm
Poison_Class
3
Exposure effects
Chronic ingestion may cause liver damage. May cause reproductive and fetal effects.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause auditory and visual hallucinations, disorientation, sweating, and
   Inhalation
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Aspiration may lead to pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
Causes skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of ingestion. May cause cyanosis of the extremities.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
USCG CHRIS Code
DLS
 
HS Code
2924 19 00
 
Std. Transport #
4913246
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S