Dimethyl fumarate

  • Methyl fumarate
  • Dimethyl trans-ethylenedicarboxylate
  • Allomaleic acid dimethyl este
  • Boletic acid dimethyl ester
  • trans-Butenedioic acid dimethyl ester
  • (2E)-2-Butenedioic acid dimethyl ester
Formula
CH3OOCCH=CHCOOCH3
Structure
Description
White crystalline powder.

Registry Numbers and Inventories.
CAS
624-49-7
EC (EINECS/ELINCS)
210-849-0
EC Class
harmful, irritant, sensitizing
R 21 36/37/38
S 26 36/37/39
RTECS
EM6125000
RTECS class
Primary Irritant
Merck
13,4308
Beilstein/Gmelin
774590
Beilstein Reference
4-02-00-02205
Swiss Giftliste 1
G-4768
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H8O4
Formula mass
144.13
Melting point, °C
102
Boiling point, °C
192
Vapor pressure, mmHg
0.48 (25 C)
Vapor density (air=1)
5.0
Density
1.37 g/cm3 (20 C)
Solubility in water
Soluble
Surface tension
25.67 g/s2 (106 C)
Refractive index
1.4037 (110.7 C)
Partition coefficient, pKow
0.62
Heat of fusion
34.9 kJ/mol
Heat of vaporization
42.9 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids - bases - oxidizing agents - reducing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
91
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
4
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Inhalation of dust may cause respiratory tract irritation.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin. May cause reddening of the skin.
   Eyes
Contact produces irritation, tearing, and burning pain. Causes severe eye irritation and possible injury.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Get medical aid. Gently lift eyelids and flush continuously with water. Extensive irrigation is required (at least 30 minutes).

Transport.
HS Code
2917 19 90