Dimethyl sulfoxide

  • Methyl sulfoxide
  • DMSO
  • Sulfinylbismethane
  • Methanesulfinylmethane
  • Dolicur
  • Dipirartril-tropico
Formula
(CH3)2SO
Structure
Description
Clear, colorless liquid, odorless or with a light sulfur, garlic or oyster-like odor depending on purity.
Uses
Medication.

Registry Numbers and Inventories.
CAS
67-68-5
EC (EINECS/ELINCS)
200-664-3
R 36/38
RTECS
PV6210000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
13,3285
Beilstein/Gmelin
506008
Beilstein Reference
4-01-00-01277
EPA OPP
177
Swiss Giftliste 1
G-1565
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2H6OS
Formula mass
78.13
Melting point, °C
18.5
Boiling point, °C
189
Vapor pressure, mmHg
0.42 (20 C)
Vapor density (air=1)
2.7
Saturation Concentration
592 ppm (0.059%) at 20 C; 790 ppm (0.079%) (calculated)
Density
1.101 g/cm3 (20 C)
Solubility in water
Miscible
Viscosity
1.96 cp (25 C)
Surface tension
43.04 g/s2 (25 C)
Refractive index
1.4783 (20 C)
Dipole moment
3.9 D (20 C)
Dielectric constant
48.9 (20 C)
Partition coefficient, pKow
-2.03
Heat of fusion
98.43 kJ/mol
Heat of vaporization
40.8 kJ/mol
Heat of combustion
-1715 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
B3
Handling
Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Do not flush into a sewer. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Disposal code
1
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases.
Decomposition
Carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Flash Point,°C
95
Autoignition, °C
300
Upper exp. limit, %
63.0
Lower exp. limit, %
1.8
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Slightly flammable. Requires preheating.
Hazards
Poisonous gases may be produced in fire.
Combustion products
Sulfur dioxide, formaldehyde, and methyl mercaptan can form
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OEL-RUSSIA:STEL 20 mg/m3
Poison_Class
-
Exposure effects
Prolonged or repeated skin contact may cause dermatitis. May cause liver and kidney damage. Effects may be delayed.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause garlic smell on the breath and body.
   Inhalation
May cause respiratory tract irritation. Can produce delayed pulmonary edema.
   Skin
May cause irritation with burning pain, itching and redness. Substance is rapidly absorbed through the skin.
   Eyes
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
USCG CHRIS Code
DMS
 
HS Code
2930 90 70
 
Std. Transport #
4914171