Diphenadione

  • PCQ
  • U-1363
  • Didandin
  • Didion
  • Dipaxin
  • Diphacin
Formula
C23H16O3
Structure
Description
Odorless pale yellow crystals.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
82-66-6
EC (EINECS/ELINCS)
201-434-5
EC Index Number
606-038-00-X
EC Class
Very toxic; Toxic
RTECS
NK5600000
RTECS class
Agricultural Chemical and Pesticide; Drug
UN (DOT)
1325
Merck
12,3363
Beilstein/Gmelin
2060511
Beilstein Reference
4-07-00-02838
EPA OPP
67701
Swiss Giftliste 1
G-4005
New Zealand
Listed

Properties.
Formula
C23H16O3
Formula mass
340.38
Melting point, °C
146 - 147
Density
1.281 g/cm3 (20 C)
Solubility in water
practically insoluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal.
Stability
No data.
Incompatibilities
Reacts with many acids and bases liberating heat and flammable gases (e.g., H2) Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides Reacts violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Fire.
Fire fighting
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site.The material is similar to coumarin and indandione. (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
Fire potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.
Hazards
When heated to decomposition it emits acrid smoke and fumes. Sensitive to light.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Poison_Class
1
Exposure effects
Neurologic damage has been seen in experimental animals. No data were available to assess the specific to diphacinone. <br>HUMAN TERATOGEN - Some coumarin anticoagulants, primarily WARFARIN, have been linked with human birth defects. Characteristic skeletal defects, called FETAL WARFARIN SYNDROME, arise when exposure is during the first trimester (Schardein, 1985). <br>The indandiones are excreted in breast milk.
   Ingestion
Spontaneous emesis and bloody stools may occur.
   Inhalation
Pulmonary edema has been produced by ingestion of diphacinone in dogs.
   Skin
Ecchymoses and hematomas occur due to reduced clotting capacity.
   Eyes
See Skin.

First aid
 
   Ingestion
Emesis is contraindicated in patients with a prolonged pt or inr due to the risk of bleeding following ipecac-induced increased intracranial pressure. Ipecac may be indicated in the home setting for pediatric patients with an accurate history of recent one-time acute ingestion of these rodenticides. Emesis: use is controversial.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove all exposed clothing and jewelry taking necessary precautions to prevent secondary exposure to health care providers. Irrigate exposed areas promptly with copious amounts of water for at least 30 minutes. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing.
   Eyes
In case of contact with substance, immediately flush with running water for at least 20 minutes.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III
 
USCG CHRIS Code
DNN